花のイソフォームは,がんの競争力のある成長を促す
Esha Madan1,2, Christopher J Pelham2,3, Masaki Nagane4
1Champalimaud Centre for the Unknown, Lisbon, Portugal.
Nature
|July 26, 2019
まとめ
ヒトの細胞は花のタンパク質を
科学分野:
- 細胞生物学
- 発達生物学
- 癌の生物学
背景:
- 適応性免疫系は 損傷した細胞を排除しますが 他のメカニズムも存在します
- ドロソフィラは"フィットネス指紋" (花のタンパク質) を使って 細胞の選択を行い 衰老を遅らせて 変形を予防します
- 人体内の損傷した細胞の蓄積は 老化に関連した疾患に寄与します
研究 の 目的:
- ヒトでも同様の細胞適合性比較メカニズムがあるかどうかを調査する.
- 細胞選択と癌におけるヒト花 (hFWE) タンパク質の役割を理解する.
主な方法:
- ヒトフラワー (hFWE) の同型が特定され,特徴づけられた.
- 異なるhFWEアイソフォームを発現する細胞間の競争的相互作用を評価した.
- ヒトの癌細胞の増殖と化学療法への反応における hFWE タンパク質の役割を調査した.
主要な成果:
- 2つのヒトのフラワー同型 (hFWE1,hFWE3) はフラワー・ロスとして機能し,適性を低下させています.
- 2つのヒトフラワー同型 (hFWE2,hFWE4) はフラワーウィンの役割を果たし,競争上の優位性を与えます.
- Winイソフォーム発現が増加したヒトがん細胞は,Lose発現するストロマを上回り,腫瘍の成長を促進し,花のタンパク質を抑制すると腫瘍の成長と転移が減少する.
結論:
- 花のタンパク質を含む古代の細胞認識と選択メカニズムがヒトで活性化している.
- これらのメカニズムは腫瘍的成長において重要な役割を果たし,潜在的な治療目標を提供している.
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