ポリペプチドナノ粒子は,アミノ酸N-カーボキシアンヒドリドのエマルションポリメリゼーションから得られます
Jaco Jacobs1, Dražen Pavlović2, Hannah Prydderch2
1School of Chemical Sciences , Dublin City University , Glasnevin, Dublin 9 , Ireland.
Journal of the American Chemical Society
|July 27, 2019
まとめ
ポリペプチドナノ粒子を 特殊なポリメリゼーション技術で作りました 紫外線は 保護基の除去を誘発し 粒子の結合と収縮を引き起こしました
科学分野:
- ポリマー化学
- 材料科学
- ナノテクノロジー
背景:
- ポリペプチドナノ粒子は様々な科学分野において 多様な応用が可能です
- 特定のサイズと性質を持つナノ粒子の制御された合成は,高度なアプリケーションにとって極めて重要です.
- 刺激に反応する材料の開発は活発な研究分野です.
研究 の 目的:
- ポリペプチドナノ粒子をS- ((o-ニトロベンジル) -l-システインN-カルボシアン水素 (NBC NCA) のミニエムルションポリメリゼーションで合成する.
- 制御されたポリメリゼーションとナノ粒子形成のための反応条件を最適化します.
- 超紫外線照射がナノ粒子の性質に及ぼす影響を調査し,クロスリンクとサイズ縮小を含む.
主な方法:
- S- ((o-ニトロベンジル) -l-システイン N-カルボシアン水素 (NBC NCA) のミニエムルションポリメリゼーション
- 反応条件とナノ粒子のサイズを制御するプロセスの最適化 (約. 220 nm) となっている.
- ナノ粒子エムルションの紫外線照射により,インシットグループ除去とクロスリンクを誘導する.
主要な成果:
- 平均サイズ220nmのポリペプチドナノ粒子の合成に成功した.
- 水に敏感なNBC NCAのポリメリゼーション条件の最適化
- 紫外線で誘発されたニトロベンジル基の除去
- ディスルファイド結合の形成は 粒子の交絡と収縮につながります
結論:
- ポリペプチドナノ粒子は,NBC NCAのミニエムルションポリメリゼーションを使用して効果的に合成することができます.
- 紫外線照射は,クロスリンクとサイズ減少を含む合成後の改変のための制御可能な方法を提供します.
- 開発された方法は,潜在的なアプリケーションのための調整可能なポリペプチドナノ構造を作成するための経路を提供します.
関連する概念動画
Amino acids
104.6K
Amino acids are the monomers that comprise proteins. Each amino acid has the same fundamental structure, which consists of a central carbon atom, or the alpha (α) carbon, bonded to an amino group (NH2), a carboxyl group (COOH), and to a hydrogen atom. Every amino acid also has another atom or group of atoms bonded to the central atom known as the R group. There are 20 common amino acids present in proteins, each with a different R group. Variation in the amino acid sequence is responsible for...
104.6K
Amino Acid Catabolism
1.0K
Microorganisms rely on proteins as an essential carbon and energy source, particularly in environments with limited polysaccharides or lipids. However, proteins are too large to cross the plasma membrane unaided, necessitating enzymatic degradation. Microbes secrete extracellular proteases and peptidases that hydrolyze proteins into peptides, which can then be transported across the membrane. Once inside the cell, intracellular proteases degrade these peptides into free amino acids, which...
1.0K
Amino Acid Biosynthetic Pathways
1.1K
Amino acid biosynthesis is essential for cell growth, protein synthesis, and metabolic regulation. Cells generate essential and non-essential amino acids from metabolic intermediates to sustain vital biological functions. These intermediates originate from key metabolic pathways: glycolysis, the tricarboxylic acid (TCA) cycle, and the pentose phosphate pathway. Important precursors include α-ketoglutarate, pyruvate, oxaloacetate, phosphoenolpyruvate, and erythrose-4-phosphate, which...
1.1K
Phase II Reactions: Sulfation and Conjugation with α-Amino Acids
904
Sulfation and α-amino acid conjugation are two critical biotransformation reactions in drug metabolism. Sulfation, a phase II biotransformation reaction, involves adding a polar sulfate group to a drug, enhancing its water solubility and promoting excretion. This process can either co-occur with or occur independently of glucuronidation. Nonmicrosomal sulfotransferase enzymes catalyze the process. The reaction involves 3'-phosphoadenosine-5'-phosphosulfate or PAPS coenzyme...
904
Nucleic Acids
49.8K
Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
49.8K
Olefin Metathesis Polymerization: Ring-Opening Metathesis Polymerization (ROMP)
3.1K
Ring-opening metathesis polymerization or ROMP involves strained cycloalkenes as starting materials. The mechanism of ROMP proceeds by reacting cycloalkene with Grubbs catalyst to give metallacyclobutane intermediate which undergoes a ring-opening reaction to form new carbene. The new carbene reacts with another molecule of cycloalkene. Repetition of these steps leads to the formation of an unsaturated open-chain polymer product. All these steps are reversible, however, relieving the ring...
3.1K


