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Updated: Jan 21, 2026

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
05:33

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines

Published on: November 9, 2020

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小分子はTMED9を標的とし,タンパク質病変を逆転させるためのリソソーム分解を促進する

Moran Dvela-Levitt1, Maria Kost-Alimova2, Maheswarareddy Emani1

  • 1Broad Institute of MIT and Harvard, Cambridge, MA, USA; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

Cell
|July 27, 2019
PubMed
まとめ

新しい小分子BRD4780は,TMED9受容体を標的にして,毒性Mucin 1腎疾患 (MKD) のタンパク質集積物を除去する. この発見は,MKDやその他のタンパク質病変の治療戦略に希望を示しています.

キーワード:
COPベシクルERのストレスゴルギ装置貨物受信機エンドプラズマの網膜皮質細胞腎臓オーガノイド分泌経路解き放たれたタンパク質反応

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