関連する実験動画

Updated: Jan 21, 2026

Preparation of High-Temperature Sample Grids for Cryo-EM
05:05

Preparation of High-Temperature Sample Grids for Cryo-EM

Published on: July 26, 2021

4.2K

グループIIの冷凍-EM構造 イントロンのDNAへの逆分割

Daniel B Haack1, Xiaodong Yan1, Cheng Zhang2

  • 1Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093, USA.

Cell
|July 27, 2019
PubMed
まとめ

グループIIのイントロンは DNAを複製するためにレトロトランポジションを使用します. Cryo-EM構造は,マチュラーゼタンパク質とドメインVIダイナミクスがDNA統合をどのように促進し,スプライセソームのレトロエレメント起源を示唆するかを明らかにする.

キーワード:
RNA構造クリオ・エムグループII イントロンマチュラゼレトロエレメントリボジームスプライソームスプライシング

さらに関連する動画

Routine Collection of High-Resolution cryo-EM Datasets Using 200 KV Transmission Electron Microscope09:49

Routine Collection of High-Resolution cryo-EM Datasets Using 200 KV Transmission Electron Microscope

Published on: March 16, 2022

5.9K
Cryo-EM and Single-Particle Analysis with Scipion09:06

Cryo-EM and Single-Particle Analysis with Scipion

Published on: May 29, 2021

4.4K

関連する概念動画

RNA Splicing01:32

RNA Splicing

Splicing is the process by which eukaryotic RNA is edited before its translation into protein. The RNA strand transcribed from eukaryotic DNA is called the primary transcript. The primary transcripts that become mRNAs are called precursor messenger RNAs (pre-mRNAs). Eukaryotic pre-mRNA contains alternating sequences of exons and introns. Exons are nucleotide sequences that code for proteins, whereas introns are the non-coding regions. In RNA splicing, introns are removed and exons are bonded...
60.4K
Alternative RNA Splicing02:18

Alternative RNA Splicing

Alternative RNA splicing is the regulated splicing of exons and introns to produce different mature mRNAs from a single pre-mRNA. Unlike in constitutive splicing where a single gene produces a single type of mRNA, alternative splicing allows an organism to produce multiple proteins from a single gene and plays an important role in protein diversity.
There are five types of alternative RNA splicing that vary in the ways the pre-mRNA segments are removed or retained in the mature mRNA. The first...
24.7K
Alternative RNA Splicing02:18

Alternative RNA Splicing

4.9K
Chromatin Structure and RNA Splicing02:41

Chromatin Structure and RNA Splicing

3.3K
Chromatin Structure Regulates pre-mRNA Processing02:41

Chromatin Structure Regulates pre-mRNA Processing

In eukaryotic cells, nascent mRNA transcripts need to undergo many post-transcriptional modifications to reach the cell cytoplasm and translate into functional proteins. For a long time, transcription and pre-mRNA processing were considered two independent events that occur sequentially in the cell. However, it has now been well established that transcription and pre-mRNA processing are two simultaneous processes that are precisely regulated inside the cell.
The chromatin structure, especially...
8.1K
DNA-only Transposons02:57

DNA-only Transposons

DNA-only transposons are called autonomous transposons since they code for the enzyme transposase that is required for the transposition mechanism. Insertion of transposons can alter gene functions in multiple ways. They can mutate the gene, alter gene expression by introducing a novel promoter or insulator sequence, introduce new splice sites, and change the mRNA transcripts produced, or remodel chromatin structure.
The donor site from where the transposon is excised is either degraded or...
17.3K