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報酬に対するモチベーションを抑制するパラニグラルVTAノシセプチン回路
Kyle E Parker1, Christian E Pedersen2, Adrian M Gomez1
1Departments of Anesthesiology, Division of Basic Research, Anatomy and Neurobiology, and Washington University Pain Center, Washington University School of Medicine, St. Louis, MO, USA.
Cell
|July 27, 2019
まとめ
研究者達は,報酬の探求を制御する,腹部タグメンタル領域 (VTA) のノシセプチン (Pnoc) ニューロンを含む新しい脳回路を特定しました. このPnoc-VTA経路は 自然な報酬への動機付けを制限し 報酬行動に影響します
科学分野:
- 神経科学
- 行動神経科学
- 分子精神医学
背景:
- ノシセプチンとその受容体 (NOPR) は,報酬行動に関連した脳領域に存在します.
- 動機付けられた行動におけるノシセプチン信号の正確な役割とタイミングは不明である.
研究 の 目的:
- 報酬を求める行動における ノシセプチンペプチド回路の機能を調査する
- モチベーションの調節に関与する特定のニューロン集団と経路を特定する.
主な方法:
- 特定のニューロンを標的とするプレプロノシセプチン (Pnoc) - クレマウスラインの生成.
- オペラントの行動中のニューロンの活動を記録する光ファイバー測定法.
- オプトジェネティックとケモジェネティック技術で ニューロンの操作をします
- VTAにおけるノシセプチン受容体 (NOPR) の条件付きデレーション
主要な成果:
- Pnoc を発現するパラニグラル・ベントラル・テグメンタル領域 (pnVTA) の異なるサブ集団が特定されました.
- pnVTAPnoc ニューロンの活動は 報酬を求める行動が止まった時にピークに達しました
- pnVTAPnocニューロンの除去または抑制,またはVTA NOPRの削除により,報酬に対するオペラント反応が強化されます.
- pnVTAPnocニューロンの活性化は,報酬回避と動機づけの減少につながった.
結論:
- pnVTAPnoc核とVTA NOPRのシグナリングは,報酬の動機を調節するために重要です.
- この研究は報酬に対する動機を 制限する新しい神経調節回路を明らかにしています
- この発見は 動機づけられた行動の 神経的基盤についての洞察を与えてくれます
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