関連する実験動画

Updated: Jan 21, 2026

Optimized Transfection Strategy for Expression and Electrophysiological Recording of Recombinant Voltage-Gated Ion Channels in HEK-293T Cells
12:59

Optimized Transfection Strategy for Expression and Electrophysiological Recording of Recombinant Voltage-Gated Ion Channels in HEK-293T Cells

Published on: January 19, 2011

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静止状態の構造と電圧ゲートされたナトリウムチャネルのゲートメカニズム

Goragot Wisedchaisri1, Lige Tonggu2, Eedann McCord1

  • 1Department of Pharmacology, University of Washington, Seattle, WA 98195, USA.

Cell
|July 30, 2019
PubMed
まとめ

研究者は,電圧ゲートされたナトリウム (NaV) チャンネルの静止状態構造を解明し,S4セグメントの動きがチャネルゲートを制御する方法を明らかにした. これは,電圧センサーとアクティベーションゲート閉鎖のための完全なメカニズムを提供します.

キーワード:
Na ((V) についてX線結晶学クリオ・エムディスルファイド・クロスリンク電気生理学ゲーティング料イオンチャンネル膜タンパク質電圧センサーボルトゲートナトリウムチャネル

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Reconstitution of a Transmembrane Protein, the Voltage-gated Ion Channel, KvAP, into Giant Unilamellar Vesicles for Microscopy and Patch Clamp Studies11:42

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