関連する実験動画

Updated: Jan 21, 2026

Detecting the Ligand-binding Domain Dimerization Activity of Estrogen Receptor Alpha Using the Mammalian Two-Hybrid Assay
09:07

Detecting the Ligand-binding Domain Dimerization Activity of Estrogen Receptor Alpha Using the Mammalian Two-Hybrid Assay

Published on: December 19, 2018

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治療用リガンドは,エストロゲン受容体機能を阻害し,その運動性を損なう

Jane Guan1, Wei Zhou1, Marc Hafner2

  • 1Department of Translational Oncology, Genentech, South San Francisco, CA 94080, USA.

Cell
|July 30, 2019
PubMed
まとめ

エストロゲン受容体 (ER) 退廃を最適化することは,乳がんにおける完全な対抗性を保証するものではありません. ERの核移動を 抑制するのではなく 抑制することで ERの活動を抑制し 新しい治療戦略を 提供します

キーワード:
ER についてSERD について乳がんクロマチンエストロゲン受容体フルヴェストラント固定する選択的なERダウンレギュレータトランスクリプション

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