人間の胎盤には微生物群はないが,潜在的病原体を含んでいる
Marcus C de Goffau1,2, Susanne Lager3,4,5, Ulla Sovio3,4
1Wellcome Sanger Institute, Cambridge, UK.
Nature
|August 2, 2019
まとめ
人間の胎盤には微生物群がなく,Streptococcus agalactiaeを除いて細菌に感染することは一般的ではありません. 妊娠前出血症のような不良結果と 細菌の存在は関連していません.
科学分野:
- 微生物学
- 産婦人科
- 新生児の健康
背景:
- 妊娠前出血症,早産,胎児の成長制限などの不良の結果は,重大な懸念事項です.
- 妊娠中の合併症における胎盤微生物群の役割は未だに議論されている.
- 以前の研究では,胎盤の組織に細菌の存在に関する矛盾した結果が得られました.
研究 の 目的:
- 胎盤の細菌DNAと 妊娠の不良の結果との関連を調べる
- 人間の胎盤に 独特の微生物群があるかどうか
- 胎盤のサンプルに存在する特定の細菌種を特定する.
主な方法:
- 分子技術を用いた合併症と合併症のない妊娠の胎盤サンプル分析.
- 本物の細菌信号と 実験室の汚染を区別するための 厳格な方法
- 出産前に採取した胎盤組織で 細菌DNAを検出することに焦点を当てます
主要な成果:
- 大半の胎盤のサンプルには 細菌の存在の証拠はありませんでした
- 検出されたバクテリア信号は 主に分娩中に感染したものです
- 産前サンプルの約5%にStreptococcus agalactiae (グループBのStreptococcus) が検出され,これは潜在的に生後獲得部位を示唆している.
結論:
- 胎盤の細菌感染は妊娠の悪影響の原因ではない.
- 人間の胎盤には 微生物群がありません
- 胎盤は新生児の症の重要な原因であるStreptococcus agalactiaeの産後獲得の場所として機能する.
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