リジン採集は抗酸化戦略であり,地下ポリアミン代謝を誘発する

Viridiana Olin-Sandoval^1,2, Jason Shu Lim Yu³, Leonor Miller-Fleming^1,4

¹Department of Biochemistry, University of Cambridge, Cambridge, UK.

Nature

|August 2, 2019

まとめ

酵母細胞は代謝を変えることで酸化ストレスに適応しますポリアミンの生成を促進しグルタチオンを増やし酸化剤耐性を高めます

科学分野:

細胞生物学
生物化学
微生物学

背景:

生物は環境の変化に対して抗ストレスメカニズムに依存しています
メタボリックシフトはストレス反応の鍵です
酵母ポリアミントランスポーターTpo1pの酸化抵抗における機能は不明であった.

研究の目的:

微生物のストレス抵抗に対する代謝適応を調査する.
ストレス下でのポリアミンとライシン代謝の関係を調べる
栄養素の摂取がストレス対策にどう影響するか

主な方法:

メタボリックリンクを特定するためのプロテオミック・タイムコース実験.
ポリアミン経路酵素を含む酵素反応の分析
栄養素の吸収,酸化還元代謝,および活性酸素種レベルの測定

主要な成果:

イーストの Spe1p 酵素はリジンを分解してカダベリンを形成する.
ポリアミン経路に依存し,ストレス下では細胞外リジンの吸収が著しく増加する.
NADPHをグルタチオンの代謝に誘導する.
グルタチオンの濃度の上昇は,反応性酸素種を減少させ,酸化剤耐性を高めます.

結論:

栄養素の吸収は,成長だけでなく,有利な条件下で代謝の再構成にも役立ちます.
ポリアミンとライシン代謝の間の新しいリンクは,予防的なストレス保護メカニズムを提供します.
この代謝適応は,酸化攻撃に対する微生物の生存を高めます.

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