糞便微生物移植の使用の進化と新興の治療用薬
Jessica R Allegretti1, Benjamin H Mullish2, Colleen Kelly3
1Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
Lancet (London, England)
|August 6, 2019
まとめ
高通量配列解析は 腸内微生物群の変化を明らかにしますが 原因は不明です 糞便の微生物移植 (FMT) は腸の健康を回復し,C. difficileのような感染症の治療に有望である.
科学分野:
- 微生物学
- ゲノミクス
- システム生物学
背景:
- ハイ・スループット・シーケンシングと システム・バイオロジーは 腸内微生物群が 健康や病気に 果たす役割について 洞察を与えてくれます
- 腸内微生物の組成と機能の特徴的な変化は多くの疾患で観察されていますが,その因果関係は不明です.
研究 の 目的:
- 腸内微生物群を調節する 潜在的治療的応用を探る
- 臨床や研究における 糞便微生物移植 (FMT) の重要性を強調する.
主な方法:
- 健康と病気における腸内微生物群の現在の理解をレビューする.
- 治療戦略としての糞便微生物移植の検討
主要な成果:
- 現在,再発したClostridioides difficile感染症では,糞便の微生物移植が推奨されています.
- 多くの臨床試験では,他の潜在的な治療用のためにFMTを調査しています.
結論:
- 疾患における腸内微生物群の役割は,因果関係を確立するためにさらなる調査が必要です.
- 糞便の微生物移植は,C. difficile感染以外の様々な疾患に対する有望な治療法です.
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