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Visualizing the Conformational Dynamics of Membrane Receptors Using Single-Molecule FRET
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ダイナミック・プロトネーションは,薬のような分子の膜透過性に劇的な影響を与える

Zhi Yue1, Chenghan Li1, Gregory A Voth1

  • 1Department of Chemistry, James Frank Institute, and Institute for Biophysical Dynamics , The University of Chicago , Chicago , Illinois 60637 , United States.

Journal of the American Chemical Society
|August 7, 2019
PubMed
まとめ

充電された薬が膜に浸透することは,ダイナミックな中和によってよりよく理解されます. この研究は,プロプラノロルが脂質界面でどのように中和し,薬物の吸収と発達のモデルを改善することを明らかにしています.

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