水中の超分子共ポリマーを模倣する自己組み立てグリコカリクスの配列を解明する
Simone I S Hendrikse1, Lu Su1, Tim P Hogervorst2
1Institute for Complex Molecular Systems , Eindhoven University of Technology , P.O. Box 513, 5600 MB Eindhoven , The Netherlands.
Journal of the American Chemical Society
|August 8, 2019
まとめ
新しいベンゼン-1,3,5-トリカルボキシアミド (BTA) モノマーは,炭水化物の結合により,超分子組成の制御を可能にします. これは1D繊維や調節可能な特性を持つ水素ガスのような機能的な生体材料の作成を可能にします.
科学分野:
- 超分子化学
- バイオマテリアル科学
- 炭水化物の化学反応
背景:
- ポリサッカライドは生物学的機能と生物物質の発達に不可欠です.
- バイオ材料における多糖質の空間的機能化は困難です.
- ベンゼン-1,3,5-トリカルボキシアミド (BTA) ベースの超分子モノメアは機能化のためのプラットフォームを提供します.
研究 の 目的:
- 新しいグリコシル化BTAモノマーの設計と合成.
- 炭水化物添加物の超分子組成への影響を調査する.
- 調整可能な性質を持つ機能的なバイオマテリアルを開発する.
主な方法:
- 単糖と二糖でBTAモノマーを合成する.
- 超分子組立行動の特徴化 (1D繊維,ミセル).
- サッカリドの密度と特性を制御するためにBTAモノマーの共聚化.
主要な成果:
- 炭水化物の性質は 超分子ポリメリゼーションを指示しています
- BTA-GlcとBTA-Manは螺旋型の1D繊維を形成し,BTA-CelとBTA-OEG4-Manはミセルを形成する.
- コポリメリゼーションは,調整可能なサッカリド含量とダイナミック交換を持つ1D繊維を生成します.
結論:
- グライコシル化BTAモノマーは自己組織化を制御する.
- 1D繊維で調整可能なサッカリド密度は達成可能である.
- 調節可能な水素ガスを含む機能的なバイオマテリアルの開発が可能になります.
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