エキゾシスト・シリア機構の欠陥が二動脈弁疾患と大動脈狭窄を引き起こす

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Updated: Jan 21, 2026

A Rabbit Aortic Valve Stenosis Model Induced by Direct Balloon Injury
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Diana Fulmer1,2, Katelynn Toomer2, Lilong Guo2

  • 1Departments of Medicine (D.F., G.L., X.Z., Y.D., Y.S., R.A.N., J.H.L.), Medical University of South Carolina, Charleston.

Circulation
|August 8, 2019
PubMed
まとめ

主要なシリア遺伝子の遺伝的変異,特にエクソシスト複合体は,双管大動脈弁疾患と関連しています. この発見は,BAVおよび関連する心臓疾患の発達におけるシリオゲネシスの障害を意味しています.

キーワード:
EXOC5タンパク質,ヒト大動脈弁大動脈弁の狭窄双動脈弁シリア

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