関連する実験動画

Updated: Jan 21, 2026

Inducible and Reversible Dominant-negative DN Protein Inhibition
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Inducible and Reversible Dominant-negative DN Protein Inhibition

Published on: January 7, 2019

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支配的陰性効果は,骨髄性悪性腫瘍におけるTP53ミッセンスの変異の選択を促す

Steffen Boettcher1,2,3, Peter G Miller1,2,3, Rohan Sharma2,3

  • 1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

Science (New York, N.Y.)
|August 10, 2019
PubMed
まとめ

がんで頻繁に変異する腫瘍抑制遺伝子TP53は,主に機能増強 (GOF) 活動ではなく,支配的陰性効果 (DNE) を表している. このDNEは,特定のがんにおけるTP53ミセンスの変異に対して選択的優位性を提供します.

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