関連する実験動画

Updated: Jan 21, 2026

Generation of Escape Variants of Neutralizing Influenza Virus Monoclonal Antibodies
07:55

Generation of Escape Variants of Neutralizing Influenza Virus Monoclonal Antibodies

Published on: August 29, 2017

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収束構造は,生殖線抗体結合とパンラッサウイルス中和の特徴を明らかにする

Kathryn M Hastie1, Robert W Cross2, Stephanie S Harkins1

  • 1La Jolla Institute for Immunology, La Jolla, CA, USA; Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA, USA.

Cell
|August 10, 2019
PubMed
まとめ

研究者らは,Lassaウイルス (LASV) の表面グリコタンパク質 (GPC) を標的とする抗体の重要な特徴を特定し,ウイルスを中和する能力を高めました. 構造による改変により,すべての主要なLASV系統に対する抗体の効能と幅が改善され,治療薬とワクチンの開発が促進されました.

キーワード:
ラッサウイルス抗体についてアレナウイルスゲルムライン中和化タンパク質工学構造生物学

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