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Updated: May 3, 2026

Fractionation for Resolution of Soluble and Insoluble Huntingtin Species
07:08

Fractionation for Resolution of Soluble and Insoluble Huntingtin Species

Published on: February 27, 2018

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ハンチントン病の発症のタイミングは,ポリグルタミンの長さによって決まります

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    Cell
    |August 10, 2019
    PubMed
    まとめ

    ハンチントン病 (HD) の発症は,ポリグルタミン分子の長さによってのみ決定されるものではありません. 代わりに,HTT CAGの繰り返し配列の不安定さは,DNA維持遺伝子の影響を受け,疾患の進行を促します.

    キーワード:
    CAG 繰り返すDNA メンテナンスDNA 修復ハンティントン病発症時の年齢病気の変化遺伝子組み換えポリグルタミン症候群ソマティックDNAの拡張トリヌクレオチドを繰り返す

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