WntとTGFβは,成長とパターンを調整して,サイズに依存する行動を制御する

Christopher P Arnold^1,2, Blair W Benham-Pyle¹, Jeffrey J Lange¹

¹Stowers Institute for Medical Research, Kansas City, MO, USA.

Nature

|August 16, 2019

まとめ

フラットワームは親のサイズに合わせて繁殖頻度を調整します信号伝達経路 (TGFβとWnt) は,このサイズに依存する分裂行動とニューロンパターンを調節する.

科学分野:

発達生物学
再生医療
動物の行動

背景:

メタゾウの体サイズと形状の多様性は,成長とパターンの違いから生じる.
組織のサイズと機能を調整するメカニズムは完全に理解されていません.
平面生物は双方向の体サイズスケーリングとサイズ依存性無性繁殖を呈する.

研究の目的:

平面性無性繁殖におけるサイズと機能の関連を調査する.
身体の大きさ,パターン,行動を調整するメカニズムを特定する.

主な方法:

スミッテア・メディテラニアで最適化された平面分裂プロトコル
前後パターン遺伝子のRNA干渉 (RNAi) スクリーン.
WntとTGFβのシグナル伝達を抑制する.

主要な成果:

子孫の数と分裂頻度は,親の平面的なサイズと相関する.
核分裂の子孫の大きさは固定され,機械的に脆弱な平面によって決定されます.
TGFβとWntの信号経路は,分裂平面の位置ではなく,分裂周波数を調節する.
WntとTGFβの抑制は,機械感覚神経のパターンと分裂行動を変化させます.

結論:

TGFβとWntのシグナル伝達経路は,平面生物のサイズに依存する生殖行動の調節に重要な役割を果たします.
この研究は,サイズ調節におけるパターニング,成長,神経機能の相互依存を明らかにしています.
機械感覚神経のパターンは体サイズに関連し,分裂行動に影響します.

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