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Updated: Jan 20, 2026

Screening Peptides that Activate MRGPRX2 using Engineered HEK Cells
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GPCRペプチドアゴニストのO-GlcNAcエンジニアリングは,その安定性と活体活性を改善します

Paul M Levine, Aaron T Balana, Emmanuel Sturchler1

  • 1Department of Molecular Medicine The Scripps Research Institute , Jupiter , Florida 33458 , United States.

Journal of the American Chemical Society
|August 17, 2019
PubMed
まとめ

O- GlcNAcylationは,GLP- 1およびPTHのような治療ペプチドの安定性とインビボ活性を強化します. この新しいアプローチはペプチドの不安定性を克服し,改善されたペプチド療法を開発するための有望な戦略を提供します.

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