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Preparation of Oligomeric β-amyloid1-42 and Induction of Synaptic Plasticity Impairment on Hippocampal Slices
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Preparation of Oligomeric β-amyloid1-42 and Induction of Synaptic Plasticity Impairment on Hippocampal Slices

Published on: July 14, 2010

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圧力ジャンプNMR光学によるβ-アミロイドペプチドオリゴメリゼーションの観察

C Ashley Barnes1, Angus J Robertson1, John M Louis1

  • 1Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases , National Institutes of Health , Bethesda , Maryland 20892 , United States.

Journal of the American Chemical Society
|August 22, 2019
PubMed
まとめ

アルツハイマー病の研究では,アミロイドベータ (Aβ) オリゴーマーが高度に秩序づけられ,毒性があることが明らかになった. 圧力ジャンプNMRは,これらのオリゴーマーが異なる構造動態を有し,Aβ毒性を理解するのに役立ちます.

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