Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Conformity01:20

Conformity

47.9K
Conformity is the change in a person’s behavior to go along with the group, even if that person does not agree with the group.
47.9K
Conformations of Butane02:20

Conformations of Butane

17.7K
Unlike ethane and propane that have only two major conformations, butane has more than two conformers. The staggered form of butane in which the bulky methyl groups on the two carbons are placed on opposite sides, that is, at a dihedral angle of 180°, is the lowest energy, most stable form — called the anti conformer. This conformation is stabilized due to the absence of steric repulsion between the largely spaced out methyl groups. The other two staggered conformations are...
17.7K
Intermolecular Forces03:13

Intermolecular Forces

70.2K
Atoms and molecules interact through bonds (or forces): intramolecular and intermolecular. The forces are electrostatic as they arise from interactions (attractive or repulsive) between charged species (permanent, partial, or temporary charges) and exist with varying strengths between ions, polar, nonpolar, and neutral molecules. The different types of intermolecular forces are ion–dipole, dipole–dipole, hydrogen bonds, and dispersion; among these, dipole–dipole, hydrogen...
70.2K
Conformations of Cycloalkanes02:29

Conformations of Cycloalkanes

14.1K
Adolf von Baeyer attempted to explain the instabilities of small and large cycloalkane rings using the concept of angle strain — the strain caused by the deviation of bond angles from the ideal 109.5° tetrahedral value for sp3  hybridized carbons. However, while cyclopropane and cyclobutane are strained, as expected from their highly compressed bond angles, cyclopentane is more strained than predicted, and cyclohexane is virtually strain-free. Hence, Baeyer’s theory that...
14.1K
Conformations of Cyclohexane02:11

Conformations of Cyclohexane

15.3K
Cyclohexane does not exist in a planar form due to the high angle and torsional strain it would experience in the planar structure. Instead, it adopts non-planar chair and boat conformations.
The chair form is the most stable and derives its name from its resemblance to the “easy chair.” In the chair conformation, two carbon atoms are arranged out-of-plane — one above and one below, minimizing the torsional strain. In the chair form, the bond angle is very close to the ideal...
15.3K
Electromotive Force02:36

Electromotive Force

29.8K
Electricity is generated by either electrons or ions flowing through a solution or a conducting medium. This flow of electrons or specifically electrical charge is defined as an electric current. When electrons move through a wire, they generate an electric current. It can be recalled  that in a redox reaction, electrons are lost and gained. In the spontaneous redox reaction of zinc  with copper, when zinc is immersed in a copper ion solution, a transfer of electrons from one substance to...
29.8K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

High-Speed AFM Reveals Ligand-Dependent Supramolecular Switching of Human Phosphofructokinase-1.

Research square·2026
Same author

Lipid trapping slows ball-and-chain inactivation in a calcium-activated potassium channel.

Nature communications·2026
Same author

Single-Molecule Visualization of DNase I-Mediated DNA Cleavage by High-Speed Atomic Force Microscopy.

ACS chemical biology·2026
Same author

Lipid composition and mechanical force underlie multi-modal regulation of Piezo1 gating.

Science advances·2026
Same author

High-Speed AFM Reveals Ligand-Dependent Supramolecular Switching of Human Phosphofructokinase-1.

bioRxiv : the preprint server for biology·2026
Same author

Response to comment on "Comparative efficacy and choice of lipid-lowering drugs for cardiovascular and kidney outcomes in patients with chronic kidney disease: A systematic review and network meta-analysis".

Journal of the Formosan Medical Association = Taiwan yi zhi·2026
Same journal

Six ways to put the public at the heart of science and policy.

Nature·2026
Same journal

The complex truth about trust in science.

Nature·2026
Same journal

Have people stopped trusting science? The data tell a surprising story.

Nature·2026
Same journal

How FAIR data are helping to build trust in science.

Nature·2026
Same journal

Scientists should recognize their own political biases to build public trust.

Nature·2026
Same journal

Harmonizing standards and resources for the medical genome.

Nature·2026
関連記事をすべて見る

関連する実験動画

Updated: Jan 20, 2026

Spatial Separation of Molecular Conformers and Clusters
10:37

Spatial Separation of Molecular Conformers and Clusters

Published on: January 9, 2014

11.7K

PIEZO1における力による形状の変化

Yi-Chih Lin1,2, Yusong R Guo3, Atsushi Miyagi1,2

  • 1Department of Anesthesiology, Weill Cornell Medicine, New York, NY, USA.

Nature
|August 23, 2019
PubMed
まとめ
この要約は機械生成です。

電気信号に力を変換するタンパク質であるPIEZO1は,細胞膜平面に逆向きに平らげることができます. この形状の変化は,PIEZO1が機械的な力にどのように反応するかの鍵です.

さらに関連する動画

Conformable Wearable Electrodes: From Fabrication to Electrophysiological Assessment
10:03

Conformable Wearable Electrodes: From Fabrication to Electrophysiological Assessment

Published on: July 22, 2022

4.9K
Utilizing Time-Resolved Protein-Induced Fluorescence Enhancement to Identify Stable Local Conformations One α-Synuclein Monomer at a Time
07:56

Utilizing Time-Resolved Protein-Induced Fluorescence Enhancement to Identify Stable Local Conformations One α-Synuclein Monomer at a Time

Published on: May 30, 2021

3.6K

関連する実験動画

Last Updated: Jan 20, 2026

Spatial Separation of Molecular Conformers and Clusters
10:37

Spatial Separation of Molecular Conformers and Clusters

Published on: January 9, 2014

11.7K
Conformable Wearable Electrodes: From Fabrication to Electrophysiological Assessment
10:03

Conformable Wearable Electrodes: From Fabrication to Electrophysiological Assessment

Published on: July 22, 2022

4.9K
Utilizing Time-Resolved Protein-Induced Fluorescence Enhancement to Identify Stable Local Conformations One α-Synuclein Monomer at a Time
07:56

Utilizing Time-Resolved Protein-Induced Fluorescence Enhancement to Identify Stable Local Conformations One α-Synuclein Monomer at a Time

Published on: May 30, 2021

3.6K

科学分野:

  • バイオ物理学
  • 分子生物学
  • 細胞生物学

背景:

  • PIEZO1は,機械的な力を細胞信号に変換するために重要な機械感受性イオンチャネルです.
  • 以前の研究では,PIEZO1のボウル状の三角構造が,腕を伸ばしていることが明らかになった.

研究 の 目的:

  • 異なる機械的条件下でのPIEZO1の構造ダイナミクスを調査する.
  • PIEZO1が膜の緊張と力に反応するメカニズムを解明する.

主な方法:

  • 電子冷凍顕微鏡 (cryo-EM) を用いて,異なる大きさの脂質小胞のPIEZO1構造を観察した.
  • 高速原子力顕微鏡 (HS-AFM) で,ミカで支えられた膜のPIEZO1の変形性を分析した.
  • PIEZO1のスプリング定数を推定するために,機械的な力を適用した.

主要な成果:

  • PIEZO1は,脂質小胞のサイズによって異なる度合いの曲線を示します.
  • PIEZO1は,力にさらされると,膜平面に逆転して平らになる.
  • PIEZO1の機械定数は,力測定を用いて推定された.

結論:

  • PIEZO1の形状が変形する能力,特に平らな構造に平ら化することが示されています.
  • この形状の柔軟性は,チャンネルのゲーティングの自由エネルギー変化に横面膜の緊張の変換を支えている可能性が高い.
  • この発見は,PIEZO1によるメカニカルトランスデュークションの分子メカニズムについての洞察を提供します.