骨髄 は 食事 制限 の 際 に 免疫 記憶 を 保護 し,最適化 し て くれる
Nicholas Collins1, Seong-Ji Han1, Michel Enamorado1
1Metaorganism Immunity Section, Laboratory of Immune System Biology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Cell
|August 24, 2019
まとめ
食事制限により 記憶T細胞は骨髄に移動し エネルギーを節約します この免疫系の適応は 栄養的ストレスで感染や腫瘍に対する 保護を強化します
科学分野:
- 免疫学
- 栄養免疫学
- 細胞生物学
背景:
- 哺乳類の免疫システムは 食物供給の変動に直面しています
- 免疫系が一時的な栄養的ストレスに適応する仕組みはよくわかっていない.
研究 の 目的:
- メモリーT細胞が食事制限にどのように適応するかを調査する.
- 栄養ストレスの時の免疫記憶における 骨髄の役割を理解するためです
主な方法:
- 食事制限下で二次リンパ性臓器と骨髄における記憶T細胞の動態を研究した.
- T細胞ホーミングにおけるグルココルチコイド,アディポサイト,および特定の分子相互作用 (CXCR4-CXCL12,S1P-S1P1R) の役割を分析した.
- 骨髄T細胞の蓄積が感染や腫瘍に対する保護に与える影響を評価した.
主要な成果:
- メモリーT細胞は二次リンパ性臓器では減少したが,食事制限中に骨髄に蓄積した.
- 骨髄T細胞は エネルギー保存状態になりました
- T細胞ホーミング因子,エリトポエーシス,アディポゲネシスの増加を含む,食事制限による骨髄再構成.
- アディポサイトと特定の分子相互作用は,骨髄におけるT細胞の蓄積を容易にした.
- 骨髄に宿る記憶T細胞は,感染や腫瘍に対する保護を強めた.
結論:
- 免疫系は 記憶T細胞を 栄養上の課題の時に 骨髄の"安全な避難所"に 再編成します
- この空間的再編成は免疫学的記憶を維持し,食事制限下で宿主の防御を強化します.
- グルココルチコイドは,この適応免疫反応の調整に重要な役割を果たします.
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