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Updated: Apr 9, 2026

A Simple Composite Phenotype Scoring System for Evaluating Mouse Models of Cerebellar Ataxia
07:33

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Published on: May 22, 2010

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アタキシン-1の損失は,脳BACE1転写を高めることでアルツハイマー病の病原性を強化する

Jaehong Suh1, Donna M Romano1, Larissa Nitschke2

  • 1Genetics and Aging Research Unit, McCance Center for Brain Health, MassGeneral Institute of Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02129, USA.

Cell
|August 24, 2019
PubMed
まとめ

アタキシン-1 (ATXN1) の損失はBACE1のレベルを上昇させ,アルツハイマー病 (AD) の病理性を悪化させます. この発見は,ATXN1機能障害がADリスクと神経変性に寄与することを示唆しています.

キーワード:
アルツハイマー病Aβ についてBACE1 についてCA2 についてアミロイド前駆体タンパク質アタクシン-1軸索をターゲットにするヒポカンプス神経生成神経変性スピノセレベラアタキシア1型

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