関連する実験動画

Updated: Jan 20, 2026

Cell Surface Receptor Identification Using Genome-Scale CRISPR/Cas9 Genetic Screens
08:49

Cell Surface Receptor Identification Using Genome-Scale CRISPR/Cas9 Genetic Screens

Published on: June 6, 2020

15.3K

生体内CRISPRスクリーンによるCD8T細胞のゲノムスケールの標的発見

Matthew B Dong1, Guangchuan Wang2, Ryan D Chow3

  • 1Department of Genetics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA; System Biology Institute, Integrated Science & Technology Center, Yale University, 850 W Campus Drive, West Haven, CT 06516, USA; Center for Cancer Systems Biology, Integrated Science & Technology Center, Yale University, 850 W Campus Drive, West Haven, CT 06516, USA; Yale MD-PhD Program, Yale University School of Medicine, New Haven, CT 06510, USA; Immunobiology Program, Yale University School of Medicine, New Haven, CT 06510, USA; Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA.

Cell
|August 24, 2019
PubMed
まとめ

全ゲノムCRISPRスクリーンは,がん免疫療法におけるCD8T細胞機能の重要なレギュラーとしてDHX37を特定した. DHX37抑制は抗腫瘍免疫を強化し,新しい治療目標を提供します.

キーワード:
CD8 T細胞DHX37 についてT細胞エフェクター機能養子縁組乳がん免疫療法in vivo CRISPRスクリーンlentiCRISPR についてターゲット発見腫瘍の浸透

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