ディペプチダゼ-1は肺と肝臓における中性粒子の徴集のための粘着受容体である
Saurav Roy Choudhury1, Liane Babes2, Jennifer J Rahn1
1Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada.
Cell
|August 24, 2019
まとめ
研究者らは,肺と肝臓への中性粒子の募集を媒介する重要な受容体としてディペプチダゼ-1 (DPEP1) を発見した. DPEP1を阻害すると,炎症が減り,内毒性モデルでの生存率が向上する.
科学分野:
- 免疫学
- 細胞生物学
- 医学 研究
背景:
- 中性粒子の募集は炎症に不可欠ですが,肺と肝臓では異なるメカニズムが働きます.
- 中性粒子の粘着の一般的な媒介体であるセレクチンとインテグリンは,肺と肝臓の炎症において小さな役割を果たします.
研究 の 目的:
- 肺と肝臓への中性粒子の増殖を制御する新しい分子標的を特定する.
- これらの臓器における中性粒子の結合と炎症反応におけるディペプチダゼ-1 (DPEP1) の役割を調査する.
主な方法:
- 肺と肝臓を誘導するペプチドを用いた in vivo 機能性スクリーニング
- 生物化学分析 遺伝的消去研究 コンフォカル・イントラバイタル・イメージング
- 内毒性モデルにおける中性粒子の増殖と生存の評価
主要な成果:
- 肺と肝臓への中性粒子の増殖を阻害する新種のペプチドが特定されました.
- ディペプチダゼ-1 (DPEP1) は,このペプチドの標的受容体として特定されました.
- DPEP1は,その酵素活性から独立して,中性粒子の物理的粘着受容体として機能する.
- 遺伝子またはペプチド媒介によるDPEP1の阻害により,中性粒子の浸透が著しく減少し,エンドトキシミアの生存率が改善されました.
結論:
- ディペプチダゼ-1 (DPEP1) は,中性粒子の封じ込めのための肺と肝臓内皮の重要な粘着受容体である.
- DPEP1は,肺と肝臓に影響する中性粒子の誘発性炎症疾患の治療に有望な治療標的です.
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