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Hepatic Portal System01:21

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The DNA Helix01:16

The DNA Helix

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Overview
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DNA-only Transposons02:57

DNA-only Transposons

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DNA-only transposons are called autonomous transposons since they code for the enzyme transposase that is required for the transposition mechanism. Insertion of transposons can alter gene functions in multiple ways. They can mutate the gene, alter gene expression by introducing a novel promoter or insulator sequence, introduce new splice sites, and change the mRNA transcripts produced, or remodel chromatin structure.
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From DNA to Protein03:06

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The flow of genetic information in cells from DNA to mRNA to protein is described by the central dogma, which states that genes specify the sequence of mRNAs, which in turn specify the sequence of amino acids making up all proteins. The decoding of one molecule to another is performed by specific proteins and RNAs. Because the information stored in DNA is so central to cellular function, it makes intuitive sense that the cell would make mRNA copies of this information for protein synthesis...
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Protein Complex Assembly02:41

Protein Complex Assembly

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Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
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Protein Complexes with Interchangeable Parts01:57

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Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
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Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus KSHV
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腫瘍ヘルペスウイルスKSHVにおけるDNA包装ポータルおよびカプシド関連テグメント複合体

Danyang Gong1, Xinghong Dai2, Jonathan Jih3

  • 1Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA 90095, USA.

Cell
|August 27, 2019
PubMed
まとめ

カポシ

キーワード:
カポシ・サルコマ関連ヘルペスウイルスカプシドクリオ・エムガンマヘルペスウイルスゲノムヘルペスウイルス顕微鏡検査ポータルタグメントウイルス学

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Establishment and Quantification of De Novo Lytic Infection by Cell-free Kaposi's Sarcoma-Associated Herpesvirus
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Iterative Optimization of DNA Duplexes for Crystallization of SeqA-DNA Complexes
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Iterative Optimization of DNA Duplexes for Crystallization of SeqA-DNA Complexes

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07:02

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus KSHV

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Establishment and Quantification of De Novo Lytic Infection by Cell-free Kaposi's Sarcoma-Associated Herpesvirus
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Iterative Optimization of DNA Duplexes for Crystallization of SeqA-DNA Complexes
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科学分野:

  • 構造生物学
  • ウイルス学
  • 分子生物学

背景:

  • カポシの肉腫関連ヘルペスウイルス (KSHV) の構成は複雑で,ポータル複合体,イコサヘドラルカプシド,カプシド関連テグメント複合体 (CATC) が含まれる.
  • 以前の研究は,イコサヘドール対称性からの偏差によるKSHVの門との構造の解明に限られていた.

研究 の 目的:

  • KSHVポータル複合体の局所構造とウイルス成分との相互作用を決定する.
  • KSHVのプロカプシド形成とDNA包装のメカニズムを解明する.

主な方法:

  • シンメトリ・リラクゼッド・クライオ・電子顕微鏡 (Cryo-EM)
  • 原子モデリング
  • 構造に基づく変異性

主要な成果:

  • この研究では,KSHVポータルの原子構造とカプシドタンパク質,CATC,およびウイルスのdsDNAゲノムとの相互作用を決定した.
  • CATCの変数占有と方向性は観察され,DNA包装の際にアタッチメントの非対称的な決定に役割を果たすことを示唆しました.
  • CATCのトリプレックスに深く結合する溝が潜在的な抗ウイルス標的として特定されました.

結論:

  • KSHVポータルは,DNA包装中にプロカプシド形成とCATCの結合をオーケストラします.
  • 特定されたCATC結合部位は,KSHVに対する新しい抗ウイルス療法の開発の有望なターゲットです.