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血性心疾患の予防のための薬学的な脂質調節療法:現在のおよび将来の選択肢
Kausik K Ray1, Pablo Corral2, Enrique Morales3
1Imperial Centre for Cardiovascular Disease Prevention, School of Public Health, Imperial College London, London, UK.
Lancet (London, England)
|August 27, 2019
まとめ
高コレステロールの管理と心臓病のリスクを減らすための新しい治療法はスタチンを補完します. このレビューは,LDLコレステロール,リポプロテイン (a),トリグリセリドを標的とした新興治療法を対象としています.
科学分野:
- 心血管医学
- 薬理学について
- 代謝 疾患
背景:
- 動脈硬化症と心臓病は 世界的な健康問題です
- 予防には ライフスタイルの変更や高血圧や脂質不全などの 心血管リスク因子の管理を含む 多要素アプローチが必要です
- 低密度脂質タンパク質 (LDL) コレステロールは,スタチンが第一線療法として介入の主要なターゲットです.
研究 の 目的:
- LDLコレステロール,リポプロテイン,トリグリセリドを下げるための現行および新興の薬理学的治療法をレビューする.
- 缺血性心臓病の予防のための治療法の概要を提供するためです.
- スタチンを受容できない,またはLDLコレステロールをさらに低下させる必要がある患者のための代替療法および追加療法について議論する.
主な方法:
- 脂質改変のための利用可能なおよび新興の治療法の文献レビュー.
- 新種の脂質低下剤の臨床試験データの分析
- 脂質タンパク質とトリグリセリドの作用を裏付ける証拠の含有
主要な成果:
- スタチンはLDLコレステロールの薬学的な低下の基石です.
- 新興療法には,エゼチミブ,PCSK9阻害剤,ベンペド酸,インクリシランが含まれ,コレステロール代謝の様々な経路を標的としています.
- 新興の証拠は,高血脂タンパク質とトリグリセリドの因果的な役割を強調しています.
結論:
- スタチン以外にも,脂質不全症の管理と心不全症の予防のための様々な薬学的選択肢があります.
- 新しい治療法により,LDLコレステロールをさらに低下させ,他のアテロゲン性リポタンパク質を治療できます.
- 複数の脂質パラメータをターゲットにした総合的な管理戦略は,心血管疾患のリスクを減らすために不可欠です.
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