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Updated: Jan 20, 2026

In Vitro Imaging and Quantification of the Drug Targeting Efficiency of Fluorescently Labeled GnRH Analogues
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In Vitro Imaging and Quantification of the Drug Targeting Efficiency of Fluorescently Labeled GnRH Analogues

Published on: March 21, 2017

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シルフォナミドシアロシドアナログで,SIGLEC-8と-Fを免疫細胞に標的とする

Corwin M Nycholat1, Shiteng Duan1, Eva Knuplez2

  • 1Department of Molecular Medicine , The Scripps Research Institute , La Jolla , California 92037 , United States.

Journal of the American Chemical Society
|August 29, 2019
PubMed
まとめ

研究者らは,シグレック-8とシグレック-Fのための新しい高親和性リガンドを開発し,免疫細胞に標的を絞ったリポソームの配送を可能にしました. この進歩は,エオシノフィルおよびマスト細胞疾患における細胞指向治療のための有望な戦略を提供します.

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Selectively labeled fluorescent GnRH-I, -II and -III derivatives are reliable tools for tracking and quantifying their cellular uptake. This manuscript introduces experiments to visualize, quantify and compare the uptake efficiency of these GnRH conjugates in various cell...
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