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Updated: Jan 20, 2026

Assembly of Complex Microtubule Structures
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Assembly of Complex Microtubule Structures

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人間のT細胞受容体CD3複合体の構造的構成

De Dong1, Lvqin Zheng2,3, Jianquan Lin1

  • 1HIT Center for Life Sciences, School of Life Science and Technology, Harbin Institute of Technology, Harbin, China.

Nature
|August 29, 2019
PubMed
まとめ

この研究は,T細胞受容体 (TCR) - CD3複合体の構造を明らかにし,その構成要素の組み立て方法を詳細に説明しています. このアセンブリメカニズムを理解することは T細胞の機能と新しい免疫療法の開発の鍵です

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Complex microtubule structures are present in resting cells and in dividing cells. In resting cells, they are responsible for maintaining the cellular architecture, tracks for intracellular transport, positioning of organelles, assembly of cilia and flagella. They mediate the bipolar spindle assembly for chromosomal segregation and positioning of the cell division plate in dividing cells. The formation of microtubule complex structures depends on the cell type, cell stage, and cell function.
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