関連する実験動画

Updated: Jan 20, 2026

Measuring Properties of the Membrane Periodic Skeleton of the Axon Initial Segment using 3D-Structured Illumination Microscopy 3D-SIM
07:40

Measuring Properties of the Membrane Periodic Skeleton of the Axon Initial Segment using 3D-Structured Illumination Microscopy 3D-SIM

Published on: February 11, 2022

2.4K

膜関連周期性骨格は,ニューロンにおけるRTKトランザクティベーションのシグナリングプラットフォームである

Ruobo Zhou1,2,3, Boran Han1,2,3, Chenglong Xia1,2,3

  • 1Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA.

Science (New York, N.Y.)
|August 31, 2019
PubMed
まとめ

ニューロンはシグナル伝達を調節するために膜関連周期性骨格 (MPS) を利用する. このダイナミックな支架は受容体を採用し,Gタンパク質結合受容体 (GPCR) と細胞結合分子 (CAM) の相互作用を可能にし,細胞外信号調節キナーゼ (ERK) のような下流信号伝達経路を活性化します.

さらに関連する動画

Carbon Skeletons, Organic Compounds and Isomers01:12

Carbon Skeletons, Organic Compounds and Isomers

114.2K
A Model Membrane Platform for Reconstituting Mitochondrial Membrane Dynamics10:31

A Model Membrane Platform for Reconstituting Mitochondrial Membrane Dynamics

Published on: September 2, 2020

8.0K

関連する概念動画

Measuring Properties of the Membrane Periodic Skeleton of the Axon Initial Segment using 3D-Structured Illumination Microscopy (3D-SIM)07:40

Measuring Properties of the Membrane Periodic Skeleton of the Axon Initial Segment using 3D-Structured Illumination Microscopy (3D-SIM)

The present protocol describes a method to visualize and measure actin rings and other components of the membrane periodic skeleton of the axon initial segment using cultured rat hippocampal neurons and 3D-structured illumination microscopy...
2.4K
Carbon Skeletons01:12

Carbon Skeletons

Life on Earth is carbon-based, as all macromolecules that make up living organisms contain carbon atoms. All organic compounds have a carbon backbone. Each carbon atom is tetravalent and can bond with four other atoms, making it an extraordinarily flexible component of biological molecules. Because carbon’s valence electrons are stable, it rarely becomes an ion. As the carbon chain increases in length, structural modifications such as ring structures, double bonds, and branching side...
114.2K
A Model Membrane Platform for Reconstituting Mitochondrial Membrane Dynamics10:31

A Model Membrane Platform for Reconstituting Mitochondrial Membrane Dynamics

Mitochondrial fusion is an important homeostatic reaction underlying mitochondrial dynamics. Described here is an in vitro reconstitution system to study mitochondrial inner-membrane fusion that can resolve membrane tethering, docking, hemifusion, and pore opening. The versatility of this approach in exploring cell membrane systems is...
8.0K
Dissection and Flat-mounting of the Threespine Stickleback Branchial Skeleton08:02

Dissection and Flat-mounting of the Threespine Stickleback Branchial Skeleton

The branchial skeleton, including gill rakers, pharyngeal teeth, and branchial bones, serves as the primary site of food processing in most fish. Here we describe a protocol to dissect and flat-mount this internal skeleton in threespine sticklebacks. This method is also applicable to a variety of other fish species.
10.3K
A Multi-compartment CNS Neuron-glia Co-culture Microfluidic Platform13:24

A Multi-compartment CNS Neuron-glia Co-culture Microfluidic Platform

We developed a novel multi-compartment neuron co-culture microsystem platform for in vitro CNS axon-glia interaction research. The platform is capable of conducting up to six independent experiments in parallel and was fabricated using a newly developed macro/micro hybrid fabrication method.
12.4K
In Vivo Recording of Intracellular Signals from a Single Neuron02:36

In Vivo Recording of Intracellular Signals from a Single Neuron

This video demonstrates the recording of electrical signals from single brain neurons using a fine-tipped glass micropipette and a specialized setup. The micropipette is carefully inserted into the rat's brain and is buzzed to penetrate the neuron to record internal neuronal electrical...
938