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Updated: May 8, 2026

Functional Characterization of Regulatory Macrophages That Inhibit Graft-reactive Immunity
08:41

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Published on: June 7, 2017

クローン病の病変の単細胞分析は,抗TNF治療に対する耐性に関連した病原性細胞モジュールを特定する

Jerome C Martin1, Christie Chang1, Gilles Boschetti1

  • 1Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Cell
|September 3, 2019
PubMed
まとめ

特定の細胞モジュールであるGIMATSは,イレアルクローン病 (iCD) の病変において,抗TNF治療に対する弱い反応を予測する. このモジュールを特定することで クローン病患者の治療戦略が改善される可能性があります.

キーワード:
クローン病高次元プロファイリング炎症性腸疾患分子分類単細胞RNAシーケンシング

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Evaluating Therapeutic Interventions in the SHIP-deficient Mouse Model of Crohn Disease-like Ileitis and Fibrosis09:44

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