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Updated: Jan 20, 2026

DNA Methylation Analysis
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DNA Methylation Analysis

Published on: April 30, 2023

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ヒストンマークH3K36me2はDNMT3Aを採用し,遺伝子間のDNAメチル化パターンを形成する

Daniel N Weinberg1, Simon Papillon-Cavanagh2, Haifen Chen2

  • 1Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, NY, USA.

Nature
|September 6, 2019
PubMed
まとめ

ヒストンメチルトランスフェラーゼNSD1は,DNAメチルトランスフェラーゼDNMT3Aをインタージェニック領域に誘導し,DNAメチル化を維持する. 変異によってこの経路が破壊され 異常なメチル化が発達障害や癌に繋がります

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