Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Heterotopic Auxiliary Rat Liver Transplantation With Flow-regulated Portal Vein Arterialization in Acute Hepatic Failure16:19

Heterotopic Auxiliary Rat Liver Transplantation With Flow-regulated Portal Vein Arterialization in Acute Hepatic Failure

13.2K
Auxiliary liver transplantation provides a temporary support in acute hepatic failure, until regeneration of the failing liver. The heterotopic auxiliary liver transplantation (HALT) with portal vein arterialization (PVA) renders sufficient liver function. We developed an analogous technique in the rat, to examine the influence of the portal vein arterialization on the morphology and function of the...
13.2K
Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen09:44

Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen

11.0K
The acute liver failure animal model developed in the current study presents a feasible alternative for the study of potential therapies. The current model employs the combined effect of physical and drug-induced hepatic injury and provides a suitable time window to study the potential of novel...
11.0K
Acute Respiratory Failure-I01:21

Acute Respiratory Failure-I

883
Acute respiratory failure is a condition characterized by the inability of the lungs to perform their primary function: gas exchange. This failure leads to insufficient oxygen levels (hypoxemia) in the blood, elevated carbon dioxide levels (hypercapnia), or both, causing critical impairment in organ function.
Definition: It is defined by specific criteria based on blood gas measurements. Hypoxemia happens when the partial pressure of oxygen (PaO2) falls below 60 mmHg. At the same time,...
883
Acute Respiratory Failure-II01:21

Acute Respiratory Failure-II

1.0K
Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
1.0K
Acute Respiratory Failure-V01:29

Acute Respiratory Failure-V

470
The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
470
Acute Respiratory Failure-III01:30

Acute Respiratory Failure-III

801
Hypercapnic respiratory failure, also known as Type 2 or ventilatory respiratory failure, is a severe condition characterized by the body's inability to effectively remove carbon dioxide (CO2) from the bloodstream. It leads to an arterial CO2 pressure (PaCO2) exceeding 45 mmHg and a blood pH above 7.35. This situation indicates that the body's ventilatory demand, or the ventilation needed to maintain normal PaCO2 levels, surpasses its supply or the maximum gas flow achievable without...
801

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Role of viral and host factors in determining the outcome of HBV-associated acute liver failure.

Journal of translational medicine·2026
Same author

Comparison of LDH activity and LDH-M to predict death in patients with acetaminophen-induced acute liver failure.

EXCLI journal·2026
Same author

Identification of Genetic Risk Factors Associated With Herbal and Dietary Supplement-Induced Acute Liver Failure Using Whole Exome Sequencing Analysis.

Gastro hep advances·2025
Same author

Autoantibodies neutralizing type I IFNs in patients with fulminant herpes simplex virus hepatitis.

The Journal of experimental medicine·2025
Same author

The DILI-Inpt Prognostic Score to Identify Hospitalized Idiosyncratic DILI Patients at Risk for Adverse Outcomes.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association·2025
Same author

The endothelial growth factor angiopoietin-2 is an accurate prognostic biomarker in patients with acetaminophen-induced acute liver failure.

Toxicological sciences : an official journal of the Society of Toxicology·2025
Same journal

Assisted dying and the silencing of medicine's next generation.

Lancet (London, England)·2026
Same journal

Linguistic pragmatism: a woman with progressive abdominal pain in Thailand.

Lancet (London, England)·2026
Same journal

Medical compartmentalisation: a patient with chromosome 22q11.2 deletion syndrome in Japan.

Lancet (London, England)·2026
Same journal

[<sup>177</sup>Lu]Lu-edotreotide versus everolimus for gastroenteropancreatic neuroendocrine tumours (COMPETE): a phase 3, multicentre, randomised, open-label, superiority trial.

Lancet (London, England)·2026
Same journal

Research priorities for characterising Bundibugyo virus.

Lancet (London, England)·2026
Same journal

Rethinking treatment sequence in advanced gastroenteropancreatic neuroendocrine tumours.

Lancet (London, England)·2026
関連記事をすべて見る

関連する実験動画

Updated: Jan 19, 2026

Heterotopic Auxiliary Rat Liver Transplantation With Flow-regulated Portal Vein Arterialization in Acute Hepatic Failure
16:19

Heterotopic Auxiliary Rat Liver Transplantation With Flow-regulated Portal Vein Arterialization in Acute Hepatic Failure

Published on: September 13, 2014

13.2K

急性肝不全

R Todd Stravitz1, William M Lee2

  • 1Hume-Lee Transplant Center of Virginia Commonwealth University, Richmond, VA, USA.

Lancet (London, England)
|September 10, 2019
PubMed
まとめ
この要約は機械生成です。

急性肝不全は,肝細胞の急速な損傷による重症な状態で,アミノトランスフェラーゼの値が上昇し,メンテーションが変化します. 肝臓移植は重要な選択肢として残っています.

さらに関連する動画

Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen
09:44

Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen

Published on: November 27, 2019

11.0K
Histological Analyses of Acute Alcoholic Liver Injury in Zebrafish
10:45

Histological Analyses of Acute Alcoholic Liver Injury in Zebrafish

Published on: May 25, 2017

15.1K

関連する実験動画

Last Updated: Jan 19, 2026

Heterotopic Auxiliary Rat Liver Transplantation With Flow-regulated Portal Vein Arterialization in Acute Hepatic Failure
16:19

Heterotopic Auxiliary Rat Liver Transplantation With Flow-regulated Portal Vein Arterialization in Acute Hepatic Failure

Published on: September 13, 2014

13.2K
Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen
09:44

Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen

Published on: November 27, 2019

11.0K
Histological Analyses of Acute Alcoholic Liver Injury in Zebrafish
10:45

Histological Analyses of Acute Alcoholic Liver Injury in Zebrafish

Published on: May 25, 2017

15.1K

科学分野:

  • ヘパトロジー
  • 内科 医学
  • 毒理学について

背景:

  • 急性肝機能不全 (ALF) は,肝臓疾患が既にあることなく,肝細胞の急速な損傷によって特徴づけられる希少で重症な疾患です.
  • アミノトランスフェラスが増加し, メンテーションが変化し, 凝固不全がある.
  • 適切な管理のために,ALFと非補償性肝硬変を区別することが重要です.

研究 の 目的:

  • 急性肝障害の主要な特徴,原因,診断方法について概説する.
  • 現在の管理戦略と患者の治療結果への影響について議論する.
  • 肝臓移植の役割を強調する

主な方法:

  • 急性肝不全に関する既存の文献と専門家の意見のレビュー
  • 薬物毒性 (パラセタモール),缺血性,ウイルス性,自己免疫性肝炎を含む一般的な病因学的要因の分析.
  • 薬物使用歴と血清検査を含む診断基準を強調する.

主要な成果:

  • アミノトランスフェラーゼの急速な上昇,変化したメンテーション,および凝固障害の一貫したパターンはALFを定義します.
  • 一般的な原因には,パラセタモールによる毒性,ウイルス性肝炎,様々な原因による薬物誘発性肝損傷があります.
  • 希少で大規模な治験が限られているにもかかわらず,改善された管理により死亡率は減少しました.

結論:

  • 急性肝不全は,様々な病因を考慮して迅速な診断と治療を必要とします.
  • 肝臓移植は患者の30%近くにとって 命を救う重要な介入であり続けています
  • 更に研究が必要ですが 現在の専門家の指導によるアプローチは 生存率を高めています