ペンフィガス
Enno Schmidt1, Michael Kasperkiewicz2, Pascal Joly3
1Department of Dermatology, University of Lübeck, Lübeck, Germany; Lübeck Institute for Experimental Dermatology, University of Lübeck, Lübeck, Germany.
Lancet (London, England)
|September 10, 2019
まとめ
ペンフィグスは めったにない自己免疫疾患で 膀を形成します リトゥキシマブによる治療は寛解率が高く,中度から重度の症例ではコルチコステロイドによる副作用が軽減されます.
科学分野:
- 皮膚科
- 免疫学
- 自己免疫 疾患
背景:
- ペンフィガスは重度の自己免疫性水泡性疾患です.
- 病原性自己抗体はデスマグリーン (Dsg) 1とDsg3の粘着タンパク質を標的にする.
- この抗体結合は,ケラチノシートの分離 (アカントーリス) を引き起こします.
研究 の 目的:
- Pemphigusの病原性と診断の理解を要約する.
- コルチコステロイドとリトキシマブを含む現在の治療戦略を強調する.
- ペンフィガス治療におけるリトキシマブの有効性と効果を評価する.
主な方法:
- 診断には生検の直接免疫光顕微鏡検査と抗Dsg抗体の血清ELISAが必要です.
- 治療の基本はコルチコステロイドです
- リトキシマブ (抗CD20抗体) は,中等から重度の症例に使用されます.
主要な成果:
- リトキシマブは90%の患者で完全寛解を誘導する.
- リトキシマブにより,コルチコステロイドの投与量が急速に減少します.
- これは重要なコルチコステロイドを節約する効果と有害事象の減少につながります.
結論:
- リトゥキシマブは,中度から重度のペンフィガスに対する非常に効果的な治療法です.
- コルチコステロイドの減少を可能にすることで,患者のアウトカムを大幅に改善します.
- リトゥキシマブはペムフィグスの管理において,副作用の少ない大きな利点を提供します.
関連する概念動画
Prokaryotic Cells
109.1K
Prokaryotes are small unicellular organisms that include the domains—Archaea and Bacteria. Bacteria include many common organisms, such as Salmonella and E. coli, while the Archaea include extremophiles that live in harsh environments, such as volcanic springs.
Like eukaryotic cells, all prokaryotic cells are surrounded by a plasma membrane, have genetic material in the form of single, circular DNA, a cytoplasm that fills the interior of the cell, and ribosomes that synthesize proteins....
Like eukaryotic cells, all prokaryotic cells are surrounded by a plasma membrane, have genetic material in the form of single, circular DNA, a cytoplasm that fills the interior of the cell, and ribosomes that synthesize proteins....
109.1K
Cytoskeletal Proteins in Bacteria
3.5K
Bacterial cells were initially considered simple, randomly organized structures lacking a cytoskeleton. However, the discovery of cytoskeleton homologs in bacteria led to the change of this opinion. Bacterial cytoskeletal filaments regulate the cell shape, cell polarity, cell division, and partitioning of plasmids during cell division. It was later discovered that bacterial cytoskeletal proteins, mainly actin and tubulin homologs, are diverse compared to their eukaryotic counterparts. On the...
3.5K
Prokaryotic Cells
29.4K
Prokaryotes are small unicellular organisms that include the domains — Archaea and Bacteria. Bacteria include many common microorganisms, such as Salmonella and E. coli, while the Archaea include extremophiles that live in harsh environments, such as volcanic springs.
Like eukaryotic cells, all prokaryotic cells are surrounded by a plasma membrane, have genetic material in the form of single, circular DNA, a cytoplasm that fills the interior of the cell, and ribosomes that synthesize...
Like eukaryotic cells, all prokaryotic cells are surrounded by a plasma membrane, have genetic material in the form of single, circular DNA, a cytoplasm that fills the interior of the cell, and ribosomes that synthesize...
29.4K
Bacterial Flora of the Large Intestine
1.7K
The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.
1.7K
Microbes in the Production of Fermented Foods
327
Lactic acid bacteria (LAB) and molds are instrumental in fermenting plant-based foods to enhance preservation and ensure year-round availability. These microbial processes convert plant carbohydrates into organic acids and other metabolites that inhibit spoilage organisms and contribute to the sensory qualities of the final product.In sauerkraut production, cabbage goes through a microbial succession that starts with cocci such as Leuconostoc mesenteroides. These microbes begin fermentation by...
327
Microbiota of the Large Intestine
98
The large intestine hosts the most densely populated microbial ecosystem in the human body. This complex community primarily consists of anaerobic bacteria, with Bacillota (formerly Firmicutes) and Bacteroidota (formerly Bacteroidetes) as the predominant groups. The distribution of these microbes varies along different sections of the large intestine, influenced by local environmental factors such as oxygen availability and nutrient composition.The cecum, located at the beginning of the large...
98


