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The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
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ペンフィガス

Enno Schmidt1, Michael Kasperkiewicz2, Pascal Joly3

  • 1Department of Dermatology, University of Lübeck, Lübeck, Germany; Lübeck Institute for Experimental Dermatology, University of Lübeck, Lübeck, Germany.

Lancet (London, England)
|September 10, 2019
PubMed
まとめ
この要約は機械生成です。

ペンフィグスは めったにない自己免疫疾患で 膀を形成します リトゥキシマブによる治療は寛解率が高く,中度から重度の症例ではコルチコステロイドによる副作用が軽減されます.

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科学分野:

  • 皮膚科
  • 免疫学
  • 自己免疫 疾患

背景:

  • ペンフィガスは重度の自己免疫性水泡性疾患です.
  • 病原性自己抗体はデスマグリーン (Dsg) 1とDsg3の粘着タンパク質を標的にする.
  • この抗体結合は,ケラチノシートの分離 (アカントーリス) を引き起こします.

研究 の 目的:

  • Pemphigusの病原性と診断の理解を要約する.
  • コルチコステロイドとリトキシマブを含む現在の治療戦略を強調する.
  • ペンフィガス治療におけるリトキシマブの有効性と効果を評価する.

主な方法:

  • 診断には生検の直接免疫光顕微鏡検査と抗Dsg抗体の血清ELISAが必要です.
  • 治療の基本はコルチコステロイドです
  • リトキシマブ (抗CD20抗体) は,中等から重度の症例に使用されます.

主要な成果:

  • リトキシマブは90%の患者で完全寛解を誘導する.
  • リトキシマブにより,コルチコステロイドの投与量が急速に減少します.
  • これは重要なコルチコステロイドを節約する効果と有害事象の減少につながります.

結論:

  • リトゥキシマブは,中度から重度のペンフィガスに対する非常に効果的な治療法です.
  • コルチコステロイドの減少を可能にすることで,患者のアウトカムを大幅に改善します.
  • リトゥキシマブはペムフィグスの管理において,副作用の少ない大きな利点を提供します.