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Updated: Jan 19, 2026

Protein Purification-free Method of Binding Affinity Determination by Microscale Thermophoresis
10:22

Protein Purification-free Method of Binding Affinity Determination by Microscale Thermophoresis

Published on: August 15, 2013

31.3K

水のネットワークは,タンパク質へのリガンド結合の親和性を決定することができる

John F Darby, Adam P Hopkins1, Seishi Shimizu

  • 1Demuris Ltd., The Biosphere , Draymans Way, Newcastle Helix , Newcastle upon Tyne NE4 5BX , United Kingdom.

Journal of the American Chemical Society
|September 14, 2019
PubMed
まとめ

タンパク質の近くの水分子のネットワークを変化させると タンパク質の結合強度が劇的に変化します この発見は,タンパク質-リガンドの相互作用における溶媒組織の重要な役割を強調しています.

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