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Updated: Jan 19, 2026

Establishment of a High-throughput Setup for Screening Small Molecules That Modulate c-di-GMP Signaling in Pseudomonas aeruginosa
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サイクルGMP-AMPシグナリングは,細菌をウイルス感染から保護します

Daniel Cohen1, Sarah Melamed1, Adi Millman1

  • 1Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.

Nature
|September 19, 2019
PubMed
まとめ

細菌は,ファグ感染に対する防御として,サイクルGMP-AMP合成酶 (cGAS) を含むサイクルGMP-AMP (cGAMP) シグナル伝達を利用する. この古代の微生物系は ウイルスの繁殖を防ぐために 細胞死を誘発し 動物の同様の抗ウイルス経路を先導します

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