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Updated: Jan 19, 2026

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes
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Published on: August 20, 2007

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1型糖尿病の治療におけるβ細胞置換療法の進歩

Marie-Christine Vantyghem1, Eelco J P de Koning2, François Pattou3

  • 1University of Lille, European Genomic Institute for Diabetes, Lille, France; Department of Endocrinology, Diabetology and Metabolism, Centre Hospitalier Universitaire de Lille, Lille, France; Inserm, Translational Research for Diabetes, Lille, France.

Lancet (London, England)
|September 20, 2019
PubMed
まとめ

重度の低血糖症または不安定な血糖コントロールを有する1型糖尿病患者のための安全な代替手段である. この治療は糖尿病の負担を効果的に軽減し,合併症を予防し,インスリン療法が不十分である場合に有効な選択肢を提供します.

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Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
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Damage or functional impairment of β-cells inhibits insulin production, leading to diabetes. Diabetes treatment...
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The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
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After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
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