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発育不全の微生物群と帝王切開による出産における好機的病原菌のコロニー化
Yan Shao1, Samuel C Forster1,2,3, Evdokia Tsaliki4
1Host-Microbiota Interactions Laboratory, Wellcome Sanger Institute, Hinxton, UK.
Nature
|September 20, 2019
まとめ
帝王切開によって 乳児の腸内微生物群の 植民地化が妨げられ 病原体が増加します 授乳と経分娩は 健康な微生物の発達を促し 長期的に赤ちゃんの健康に 重要な役割を果たします
科学分野:
- 微生物学
- 新生児の健康
- ゲノミクス
背景:
- 乳児の腸内微生物は 産後すぐにコロニーを形成し 母体や環境要因の影響を受けます
- 早期の腸内微生物の乱れは 後世の病気と関連しています
- 帝王切開が新生児の腸内微生物群の形成に与える影響については議論が続いている.
研究 の 目的:
- 乳児の腸内微生物群の早期発育に与える影響を調査する.
- 新生児の特定の微生物の変化と関連するリスクを特定する.
- 新生児の腸内微生物の形成における 病院環境の役割を理解する
主な方法:
- 乳児の腸内微生物群 (1,679個のサンプル) と母親のサンプル (175組) の縦断採取
- ゲノム全体のメタゲノム解析と解析
- 大規模な培養と細菌株の全ゲノム配列決定
主要な成果:
- 帝王切開は母性バクテロイドの伝播を大幅に妨害し,好機的な病原菌 (エンテロコック,エンテロバクテロ,クレブシエラ) を増加させた.
- 母親の抗生物質予防療法を受けた胎児や母乳授乳されていない胎児にも同様の効果が認められたが,顕著ではなかった.
- 新生児から幼児期までの腸内微生物の組成に 大きく影響します
結論:
- 発達の方法は,生命の初期に腸内微生物群の形成を決定する重要な要素です.
- 病院での出産,特に帝王切開は 抗菌剤耐性オポルトニスト病原体によるコロニー化と関連しています
- 幼児の腸内微生物の組成は 幼児の健康と病気のリスクに 長期的な影響を及ぼします
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