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Updated: Jan 19, 2026

Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity
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UNC93B1は,TLR7のシグナリングを抑制し,自己免疫を防ぐためにシンテニン-1を募集します

Olivia Majer1, Bo Liu2, Lieselotte S M Kreuk1

  • 1Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA.

Nature
|September 24, 2019
PubMed
まとめ

トール型受容体 (TLR) チャペロンUNC93B1は,TLR7のシグナル伝達を特異的に制限し,TLR7に依存する自己免疫を防ぐ. このメカニズムは,UNC93B1がシンテニン-1に結合し,TLR7をエクソソームに分類し,活性化値を設定することを含む.

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