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Updated: Jan 18, 2026

An Integrated System to Remotely Trigger Intracellular Signal Transduction by Upconversion Nanoparticle-mediated Kinase Photoactivation
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An Integrated System to Remotely Trigger Intracellular Signal Transduction by Upconversion Nanoparticle-mediated Kinase Photoactivation

Published on: August 30, 2017

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光誘発タンパク質分解 フォトケージドプロタック

Gang Xue1, Kun Wang2, Danli Zhou1

  • 1State Key Laboratory of Chemical Oncogenomics, Engineering Laboratory for Chiral Drug Synthesis, School of Chemical Biology and Biotechnology, Shenzhen Graduate School , Peking University , Shenzhen 518055 , China.

Journal of the American Chemical Society
|October 1, 2019
PubMed
まとめ

科学者たちは,光で活性化されるとのみ,Brd4のような標的タンパク質を分解する,光細胞に囲まれたタンパク質分解標的キメラ (pc-PROTACs) を開発した. この新しい光誘導性タンパク質分解戦略は 病気の研究に新しいツールを提供します

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