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Updated: Jan 6, 2026

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants
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発がん性突然変異は,タンパク質をフォスフォチロシン部位に切り替えて信号伝達経路を再構築する

Alicia Lundby1, Giulia Franciosa2, Kristina B Emdal2

  • 1Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Faculty of Health and Medical Sciences, Blegdamsvej 3b, DK-2200 Copenhagen, Denmark; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Cell
|October 5, 2019
PubMed
まとめ

研究者は,組織におけるチロシン酸化シグナリングをマッピングするための質量スペクトロメトリ法を開発した. このアプローチは タンパク質の相互作用を解読し 変異が癌のシグナル伝達ネットワークを再構築する方法を明らかにし 腫瘍発生メカニズムへの洞察を提供します

キーワード:
EGFRSH2 についてガン 信号相互作用プロテオミクスマススペクトロメトリーペプチド・プルダウンフォスフォペプチドフォスフォプロテオミックフォスフォチロシンゼブラフィッシュ

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