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Updated: Jan 6, 2026

Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells
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Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells

Published on: April 26, 2017

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癌における非正規のBAF複合体のスプライソソーマの破壊

Daichi Inoue1,2, Guo-Liang Chew3,4, Bo Liu1

  • 1Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Nature
|October 11, 2019
PubMed
まとめ

SF3B1スプライシングファクターの変異はBRD9を抑制することで癌を引き起こす. SF3B1変異細胞のBRD9スプライシングを修正すると,腫瘍の成長が抑制され,新しい治療戦略が示唆されます.

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