腸内微生物群は,ヒストン脱酸化酵素3を通して宿主代謝の昼間リズムをプログラムする
Zheng Kuang1, Yuhao Wang1, Yun Li1
1Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Science (New York, N.Y.)
|October 12, 2019
まとめ
マウスの腸内微生物群は,ヒストン脱酸化酵素3 (HDAC3) を介して,昼間の代謝リズムをプログラムする. このメカニズムは 栄養素の吸収,脂質の吸収,肥満に影響を与え 微生物と昼間の信号を統合します
科学分野:
- 代謝の調節
- 微生物群と宿主の相互作用
- クロノバイオロジー
背景:
- シルカディアンリズムが哺乳類の代謝の基本であり,生理学的プロセスを 日常の光と闇のサイクルと同期させます
- 宿主の代謝リズムをプログラムする腸内微生物群の役割は新興の研究分野です.
研究 の 目的:
- ネズミの昼間の代謝リズムに対する腸内微生物群の作用を媒介するヒストン脱酸化酵素3 (HDAC3) の役割を調査する.
- HDAC3が宿主の代謝を調節するために微生物と昼間のシグナルを統合する分子メカニズムを解明する.
主な方法:
- マウスの小腸におけるHDAC3発現と局所化の分析.
- HDAC3の標的遺伝子の採用を評価するクロマチンの免疫流出.
- ヒストンのアセチル化,遺伝子発現,栄養素吸収,脂質吸収の測定
主要な成果:
- 腸内微生物群はHDAC3の表皮発現を誘導し,それがクロマチンにリズム的に結合する.
- HDAC3はヒストンのアセチル化,代謝遺伝子発現,栄養素吸収の昼間振動を誘導する.
- HDAC3は,非正規的にエストロゲン関連受容体αを同活性化し,リズム*Cd36*転写,脂質吸収,食事による肥満を調節する.
結論:
- HDAC3は,腸内微生物群が昼間の代謝リズムをプログラムする重要な媒介です.
- HDAC3は,脂質代謝と吸収を含む宿主の代謝プロセスを制御するために,微生物と昼間信号を統合します.
- HDAC3媒介経路をターゲットにすることで,食事と微生物群に関連した代謝障害の管理のための新しい戦略を提供することができます.
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