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Updated: Jan 5, 2026

Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
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Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission

Published on: August 16, 2018

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サクシネート受容体への種選択的抗体結合の構造的基礎

Matthias Haffke1,2, Dominique Fehlmann3, Gabriele Rummel4

  • 1Chemical Biology & Therapeutics, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland. matthias.haffke@novartis.com.

Nature
|October 25, 2019
PubMed
まとめ

研究者は,サクシネート受容体SUCNR1の結晶構造を決定し,その不活性状態と抗体結合に関する洞察を明らかにした. この構造情報は,サクシネートシグナル伝達に関連した疾患の標的治療の開発に役立ちます.

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