皮質とタラミック接続の階層的組織
Julie A Harris1, Stefan Mihalas2, Karla E Hirokawa2
1Allen Institute for Brain Science, Seattle, WA, USA. julieha@alleninstitute.org.
Nature
|November 1, 2019
まとめ
研究者は新しいトレーサー実験を用いて マウスの脳の接続をマッピングしました 大脳皮質ネットワークの 概括的なルールと 浅い階層構造を発見し 脳の組織原理を明らかにしました
科学分野:
- 神経科学
- 脳の接続性
- システム神経科学
背景:
- 哺乳類の皮質は複雑で層状の構造で 組織的原理はよくわかっていません
- 脳の接続性に関する 現在の知識は 複雑なネットワークに関する 汎用的なルールに欠けています
研究 の 目的:
- アレン・マウス・ブレイン・コネクティビティ・アトラスを 新しいトレーサー実験で拡張する
- 皮質皮質,甲状腺皮質,甲状腺皮質のプロジェクションに関する概括的な解剖学的規則を導き出す.
- マウスの皮質組織ネットワーク内の階層的組織をモデル化し予測する.
主な方法:
- ネズミの皮質とタラマスに 約1000の新しいトレーサー実験を行いました
- 投影ニューロンクラスと層の選択的なラベル付けのためにCreドライバーラインを使用した.
- 接続パターンをフィードフォワードまたはフィードバックとして分類するモデルを開発しました.
主要な成果:
- 主要な脳投影型の概括された解剖学的規則を導いた.
- 皮質とタラミック領域とネットワークモジュールに割り当てられた階層的な位置.
- マウスの脳皮質ネットワークで 浅い階層を形成していることが判明しました
結論:
- 哺乳類の脳の接続性を支配する 新しい一般的原理を確立した.
- 神経回路における階層的組織を理解するための予測モデルを提供した.
- ネズミの皮質組織内の 浅い階層的な組織を示した.
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