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Updated: Jan 4, 2026

Stem-cell Based Engineered Immunity Against HIV Infection in the Humanized Mouse Model
11:38

Stem-cell Based Engineered Immunity Against HIV Infection in the Humanized Mouse Model

Published on: July 2, 2016

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潜伏するHIVを 変換可能なCAR-T細胞で攻撃する 適応性の高い殺戮プラットフォーム

Eytan Herzig1, Kaman Chan Kim2, Thomas A Packard1

  • 1Gladstone Center for HIV Cure Research, Gladstone Institute of Virology and Immunology, San Francisco, CA 94158, USA; Departments of Medicine and Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA.

Cell
|November 1, 2019
PubMed
まとめ

新しい変換可能なCAR-T細胞プラットフォームは,潜伏するHIV貯蔵庫を含むHIVに感染した細胞を効果的に標的にし,排除します. この革新的なアプローチは ウイルスに対する免疫反応を強化することで HIV撲滅の有望な戦略を提供します

キーワード:
CAR-T についてHIVの潜伏期ミカボディT細胞療法bNAb についてHIV 抗体の大規模な中和カバーティブルCAR-T減量と制御貯水池ショック・アンド・キル

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