微生物群と社会的脳
Eoin Sherwin1, Seth R Bordenstein2, John L Quinn3
1APC Microbiome Ireland, University College Cork, Cork, Ireland.
Science (New York, N.Y.)
|November 2, 2019
まとめ
腸内微生物群は動物の社会行動に影響を与え コミュニケーションや社会性の進化に 影響を及ぼします これらの宿主-微生物の相互作用を理解することで 自閉症スペクトル障害のような人間の社会的障害に対する 新しい治療法を提供することができます
科学分野:
- 微生物学
- 神経科学
- 行動エコロジー
背景:
- 社交性は協力のような利点をもたらしますが 攻撃的になるリスクもあります
- 腸内微生物群は,宿主の神経発達と行動における役割としてますます認識されています.
- 宿主と微生物の相互作用が 社会的行動の進化を形作ったのかもしれません
研究 の 目的:
- 胃腸の微生物群が 社会的行動に及ぼす影響を調べるため
- 社交性の進化における宿主-微生物の相互作用の役割を理解する.
- ヒトの社会的障害の潜在的治療標的を特定する.
主な方法:
- 微生物群と社会的行動に関する既存の科学文献のレビュー.
- 動物モデルでの腸-脳軸を調査した研究の分析.
- 動物のコミュニケーションに対する微生物の影響に関する証拠の検討
主要な成果:
- 腸内微生物群は 神経発達や社会行動プログラムに影響を与えます
- 微生物群は,特定の種の同種の間のコミュニケーションを促進する役割を果たします.
- 宿主と微生物の相互作用は 社会的行動の進化の経路に関与しています
結論:
- 胃腸の微生物群は 宿主の社会的行動に大きく影響します
- 微生物群と脳の相互作用に関するさらなる研究は 社交性を理解するために不可欠です
- この分野は自閉症スペクトル障害 (ASD) を含む社会的障害の新たな治療戦略に期待されています.
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