幹細胞によるリンパ系リモデリング 組織再生の調整
Shiri Gur-Cohen1, Hanseul Yang1, Sanjeethan C Baksh1
1Howard Hughes Medical Institute, Robin Chemers Neustein Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY 10065, USA.
Science (New York, N.Y.)
|November 2, 2019
まとめ
リンパ毛細血管は幹細胞 (SC) の重要なニッチ成分です. SCsのセクレトームスイッチはリンパの行動を制御し,組織再生と毛皮のサイクルに影響します.
科学分野:
- 幹細胞生物学
- 組織再生
- 血管生物学
背景:
- 幹細胞 (SCs) は,専門的な微小環境 (ニッチ) に存在する組織ホメオスタシスと修復に不可欠です.
- SCニッチが組織の成長に 果たす複雑な役割は まだ解明されていません
- リンパ毛細血管は,重要なSCニッチ成分として広く認識されていません.
研究 の 目的:
- 幹細胞ニッチの重要な構成要素としてリンパ毛細血管の役割を特定し,特徴づけること.
- 組織再生中の毛胞幹細胞とリンパ毛細血管のダイナミックな相互作用を調査する.
- 幹細胞がリンパ系を制御する 分子機構を解明する
主な方法:
- マウスモデルを使って 幹細胞とニッチの相互作用を研究した
- 髪の毛の幹細胞の分泌を研究した
- 幹細胞の信号に反応する リンパ毛細血管の行動を分析した
- リンパ管の乱れと分泌体の乱れが毛皮の循環と組織再生に与える影響を調べました.
主要な成果:
- リンパ系毛細血管が 毛皮幹細胞の内蔵部分として特定された.
- 幹細胞のセクレトームスイッチが発見され,静止状態のSCはリンパドレナージを促進するためにアンジオポエチン型のタンパク質7 (Angptl7) を発現し,活性化されたSCは一時的なリンパ解離のためにアンジオポエチン型のタンパク質4 (Angptl4) にスイッチする.
- リンパ毛細血管や幹細胞の分泌の乱れが早熟な毛の葉の循環と非同期的な組織再生につながることを示した.
結論:
- リンパ毛細血管は組織再生を動的に制御する 幹細胞の重要なニッチ成分です
- 幹細胞のセクレトームは,特定のアンジオポエチンを通して,リンパの行動を制御し,組織修復プロセスに影響を与えます.
- これらのSC-リンパ相互作用を理解することで,効果的な組織再生のための幹細胞活動の調整に関する洞察が得られます.
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