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Updated: Jan 4, 2026

Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
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cisにおける二重PIK3CA変異は,PI3Kα阻害剤に対する腫瘍性および敏感性を増加させる

Neil Vasan1,2,3, Pedram Razavi1,2, Jared L Johnson3

  • 1Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Science (New York, N.Y.)
|November 9, 2019
PubMed
まとめ

癌における複数のPIK3CA変異,特に二重変異はPI3K経路の活性を増強する. これらの発見は,二重のPIK3CA変異を持つ患者がPI3Kα阻害剤による治療からより多くの利益を得ることを示唆しています.

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