腫瘍学における非コーディングRNAの役割

Frank J Slack¹, Arul M Chinnaiyan²

¹Harvard Medical School Initiative for RNA Medicine, Harvard Medical School, Boston, MA 02215, USA; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA; Department of Medicine, Harvard Medical School, Boston, MA 02215, USA.

Cell

|November 16, 2019

まとめ

非コーディングRNA (ncRNA) は細胞活動の新発見のレギュレータであり,がんにおいて重要な役割を果たしています. 研究によるとこれらの分子は腫瘍を誘発したり腫瘍を抑制したりし新しい臨床試験を促しています

科学分野:

癌生物学
分子生物学
遺伝学

背景:

歴史的に見て癌の研究はタンパク質をコードする遺伝子を優先しました
最近の発見は,細胞プロセスにおけるノンコーディングRNA (ncRNA) の重要な調節作用を強調しています.

研究の目的:

癌における ncRNAの関与の理解が進化していることを強調するためです
ncRNAのバイオマーカーと治療標的としての臨床的重要性を強調する.

主な方法:

ncRNA研究における最近の進歩のレビュー.
腫瘍生成と腫瘍抑制における ncRNA の二重役割の分析

主要な成果:

非コーディングRNA (ncRNA) は多様で一般的な分子クラスです.
ncRNAは,がん生物学において,腫瘍性および腫瘍抑制機能の両方を表している.
現在何百もの臨床試験が ncRNAを研究しています

結論:

ncRNAは癌生物学の研究におけるパラダイムシフトを表しています
ncRNAの治療と診断の可能性は大きく,拡大しています.
ncRNAに焦点を当てた臨床試験は急速に増加しており,将来が望ましいことを示しています.

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