若年期における累積血圧暴露と中年期における運動能力と認知機能

Simin Mahinrad¹, Shawn Kurian¹, Chaney R Garner¹

¹Departments of Neurology (S.M., S.K., C.R.G., A.J.N., F.A.S.), Northwestern University Feinberg School of Medicine, Chicago, IL.

Circulation

|November 22, 2019

まとめ

若い成人期から中年期までの高血圧は歩行や認知機能の低下と関連しています白質の超強度負荷はBP-歩行関係に変化しますが,BP-認知関係には変化しません.

科学分野:

神経学
心血管の健康
老化に関する研究

背景:

高血圧 (BP) は,高齢者の運動能力と認知能力の低下の重要な危険因子です.
生涯にわたるBPの長期的な影響を理解することは予防戦略にとって極めて重要です

研究の目的:

若い成人期から中年期までの累積的なBP曝露と中年期における歩行/認知機能の関連性を調査する.
脳の白質過濃度 (WMH) 負荷がこれらの関連性を変化させるかどうかを判断する.

主な方法:

CARDIA試験の参加者191人を30年間追跡した.
曲線の下の面積を用いた累積BPの計算.30年における歩行と認知の評価.
複数の線形回帰と相互作用分析を使用して,WMH効果の修正をテストする.

主要な成果:

累積したシストリックとダイアストリックの高血圧は歩行障害 (速度が遅い,歩行距離が短く,変化が大きい) と関連付けられました.
累積血圧の上昇は実行力,記憶力,全体的な領域での認知能力の低下と関連しています
WMHの負荷はBPと歩行の関連性を調節したが,BPと認知機能の関連性は調節されなかった.

結論:

青年期から中年期までの高血圧への長期的曝露は中年の歩行や認知に悪影響を及ぼします
WMHは,累積BPと歩行の関係に適度な役割を果たします.
BPの曝露と機能を結びつける脳のメカニズムを明らかにするために,さらなる縦断的な研究が必要である.

キーワード:

血圧認知能力歩き方について中年白い物質の病気若い大人

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